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An iron-sulfur domain of the eukaryotic primase is essential for RNA primer synthesis
Primases synthesise the RNA primers that are necessary for replication of the parental DNA strands. Here we report that the heterodimeric archaeal/eukaryotic primase is an iron-sulfur (Fe-S) protein. Binding of the Fe-S cluster is mediated by an evolutionarily conserved domain at the C terminus of t...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2268749/ https://ncbi.nlm.nih.gov/pubmed/17704817 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb1288 |
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