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Effects of an ActRIIB.Fc Ligand Trap on Cardiac Function in Simian Immunodeficiency Virus-Infected Male Rhesus Macaques

An important safety consideration in the use of antagonists of myostatin and activins is whether these drugs induce myocardial hypertrophy and impair cardiac function. The current study evaluated the effects of a soluble ActRIIB receptor Fc fusion protein (ActRIIB.Fc), a ligand trap for TGF-β/activi...

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Detalhes bibliográficos
Publicado no:J Endocr Soc
Main Authors: Guo, Wen, Pencina, Karol M, Gagliano-Jucá, Thiago, Jasuja, Ravi, Morris, Nancy, O’Connell, Karyn E, Westmoreland, Susan, Bhasin, Shalender
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6041778/
https://ncbi.nlm.nih.gov/pubmed/30019021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/js.2018-00099
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