MEKK2 and MEKK3 suppress Hedgehog pathway-dependent medulloblastoma by inhibiting GLI1 function

Hedgehog (Hh) pathway plays a pivotal role in diverse aspects of development and postnatal physiology. Perturbation of Hh signaling and activation of GLI1 (glioma-associated oncogene 1), a dedicated transcription factor for Hh pathway, are highly associated with several cancers, such as medulloblast...

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Vydáno v:Oncogene
Hlavní autoři: Lu, Jinqiu, Liu, Liansheng, Zheng, Mingjie, Li, Xiaoling, Wu, Ailing, Wu, Qingzhe, Liao, Cheng, Zou, Jian, Song, Hai
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6041257/
https://ncbi.nlm.nih.gov/pubmed/29662197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0249-5
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