Expression of the DNA-Binding Factor TOX Promotes the Encephalitogenic Potential of Microbe-Induced Autoreactive CD8(+) T Cells

Infections are thought to trigger CD8(+) cytotoxic T lymphocyte (CTL) responses during autoimmunity. However, the transcriptional programs governing the tissue-destructive potential of CTLs remain poorly defined. In a model of central nervous system (CNS) inflammation, we found that infection with l...

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Veröffentlicht in:Immunity
Hauptverfasser: Page, Nicolas, Klimek, Bogna, De Roo, Mathias, Steinbach, Karin, Soldati, Hadrien, Lemeille, Sylvain, Wagner, Ingrid, Kreutzfeldt, Mario, Di Liberto, Giovanni, Vincenti, Ilena, Lingner, Thomas, Salinas, Gabriela, Brück, Wolfgang, Simons, Mikael, Murr, Rabih, Kaye, Jonathan, Zehn, Dietmar, Pinschewer, Daniel D., Merkler, Doron
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6040915/
https://ncbi.nlm.nih.gov/pubmed/29768177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2018.04.005
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