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Progranulin, lysosomal regulation and neurodegenerative disease
The discovery that heterozygous and homozygous mutations in the gene encoding progranulin are causally linked to frontotemporal dementia and lysosomal storage disease, respectively, reveals previously unrecognized roles of the progranulin protein in regulating lysosome biogenesis and function. Given...
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| Publicado no: | Nat Rev Neurosci |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6040832/ https://ncbi.nlm.nih.gov/pubmed/28435163 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrn.2017.36 |
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