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Progranulin, lysosomal regulation and neurodegenerative disease

The discovery that heterozygous and homozygous mutations in the gene encoding progranulin are causally linked to frontotemporal dementia and lysosomal storage disease, respectively, reveals previously unrecognized roles of the progranulin protein in regulating lysosome biogenesis and function. Given...

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Detalles Bibliográficos
Publicado en:Nat Rev Neurosci
Autores principales: Kao, Aimee W., McKay, Andrew, Singh, Param Priya, Brunet, Anne, Huang, Eric J.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6040832/
https://ncbi.nlm.nih.gov/pubmed/28435163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrn.2017.36
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