RHBDF2-Regulated Growth Factor Signaling in a Rare Human Disease, Tylosis With Esophageal Cancer: What Can We Learn From Murine Models?

Tylosis with esophageal cancer syndrome (TOC) is a rare autosomal dominant proliferative skin disease caused by missense mutations in the rhomboid 5 homolog 2 (RHBDF2) gene. TOC is characterized by thickening of the skin in the palms and feet and is strongly linked with the development of esophageal...

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Detalles Bibliográficos
Publicado en:Front Genet
Autores principales: Hosur, Vishnu, Farley, Michelle L., Low, Benjamin E., Burzenski, Lisa M., Shultz, Leonard D., Wiles, Michael V.
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2018
Materias:
Genetics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6039722/
https://ncbi.nlm.nih.gov/pubmed/30022999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2018.00233
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