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Seamless phase IIa/IIb adaptive design with the same primary endpoint for proof of concept and dose finding
This paper considers combining a proof of concept (POC) study and a dose finding (DF) study where the POC and the DF share the same primary endpoint. An example based on real study conditions shows that compared to a conventional design the proposed adaptive design tests more active doses, with a sm...
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| Publicado en: | Contemp Clin Trials Commun |
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| Autores principales: | , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Elsevier
2018
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6039539/ https://ncbi.nlm.nih.gov/pubmed/30003170 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.conctc.2018.06.006 |
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