Proof of concept demonstration of optimal composite MRI endpoints for clinical trials

INTRODUCTION: Atrophy measures derived from structural MRI are promising outcome measures for early phase clinical trials, especially for rare diseases such as primary progressive aphasia (PPA), where the small available subject pool limits our ability to perform meaningfully powered trials with tra...

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Опубликовано в: :Alzheimers Dement (N Y)
Главные авторы: Edland, Steven D., Ard, M. Colin, Sridhar, Jaiashre, Cobia, Derin, Martersteck, Adam, Mesulam, M.-Marsel, Rogalski, Emily J.
Формат: Artigo
Язык:Inglês
Опубликовано: Elsevier 2016
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363955/
https://ncbi.nlm.nih.gov/pubmed/28345017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.trci.2016.05.002
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