Proof of concept demonstration of optimal composite MRI endpoints for clinical trials

INTRODUCTION: Atrophy measures derived from structural MRI are promising outcome measures for early phase clinical trials, especially for rare diseases such as primary progressive aphasia (PPA), where the small available subject pool limits our ability to perform meaningfully powered trials with tra...

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Detalhes bibliográficos
Publicado no:Alzheimers Dement (N Y)
Main Authors: Edland, Steven D., Ard, M. Colin, Sridhar, Jaiashre, Cobia, Derin, Martersteck, Adam, Mesulam, M.-Marsel, Rogalski, Emily J.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363955/
https://ncbi.nlm.nih.gov/pubmed/28345017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.trci.2016.05.002
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