IP6 is an HIV pocket factor that prevents capsid collapse and promotes DNA synthesis

The HIV capsid is semipermeable and covered in electropositive pores that are essential for viral DNA synthesis and infection. Here, we show that these pores bind the abundant cellular polyanion IP(6), transforming viral stability from minutes to hours and allowing newly synthesised DNA to accumulat...

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Detalles Bibliográficos
Publicado en:eLife
Autores principales: Mallery, Donna L, Márquez, Chantal L, McEwan, William A, Dickson, Claire F, Jacques, David A, Anandapadamanaban, Madhanagopal, Bichel, Katsiaryna, Towers, Gregory J, Saiardi, Adolfo, Böcking, Till, James, Leo C
Formato: Artigo
Lenguaje:Inglês
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Microbiology and Infectious Disease
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6039178/
https://ncbi.nlm.nih.gov/pubmed/29848441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.35335
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