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IP6 is an HIV pocket factor that prevents capsid collapse and promotes DNA synthesis
The HIV capsid is semipermeable and covered in electropositive pores that are essential for viral DNA synthesis and infection. Here, we show that these pores bind the abundant cellular polyanion IP(6), transforming viral stability from minutes to hours and allowing newly synthesised DNA to accumulat...
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| 出版年: | eLife |
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| 主要な著者: | , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
eLife Sciences Publications, Ltd
2018
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6039178/ https://ncbi.nlm.nih.gov/pubmed/29848441 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.35335 |
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