IP6 is an HIV pocket factor that prevents capsid collapse and promotes DNA synthesis

The HIV capsid is semipermeable and covered in electropositive pores that are essential for viral DNA synthesis and infection. Here, we show that these pores bind the abundant cellular polyanion IP(6), transforming viral stability from minutes to hours and allowing newly synthesised DNA to accumulat...

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Veröffentlicht in:eLife
Hauptverfasser: Mallery, Donna L, Márquez, Chantal L, McEwan, William A, Dickson, Claire F, Jacques, David A, Anandapadamanaban, Madhanagopal, Bichel, Katsiaryna, Towers, Gregory J, Saiardi, Adolfo, Böcking, Till, James, Leo C
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2018
Schlagworte:
Microbiology and Infectious Disease
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6039178/
https://ncbi.nlm.nih.gov/pubmed/29848441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.35335
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