IP6 is an HIV pocket factor that prevents capsid collapse and promotes DNA synthesis

The HIV capsid is semipermeable and covered in electropositive pores that are essential for viral DNA synthesis and infection. Here, we show that these pores bind the abundant cellular polyanion IP(6), transforming viral stability from minutes to hours and allowing newly synthesised DNA to accumulat...

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Pubblicato in:eLife
Autori principali: Mallery, Donna L, Márquez, Chantal L, McEwan, William A, Dickson, Claire F, Jacques, David A, Anandapadamanaban, Madhanagopal, Bichel, Katsiaryna, Towers, Gregory J, Saiardi, Adolfo, Böcking, Till, James, Leo C
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2018
Soggetti:
Microbiology and Infectious Disease
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6039178/
https://ncbi.nlm.nih.gov/pubmed/29848441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.35335
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