Inert and seed-competent tau monomers suggest structural origins of aggregation

Tauopathies feature progressive accumulation of tau amyloids. Pathology may begin when these amplify from a protein template, or seed, whose structure is unknown. We have purified and characterized distinct forms of tau monomer—inert (M(i)) and seed-competent (M(s)). Recombinant M(s) triggered intra...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Mirbaha, Hilda, Chen, Dailu, Morazova, Olga A, Ruff, Kiersten M, Sharma, Apurwa M, Liu, Xiaohua, Goodarzi, Mohammad, Pappu, Rohit V, Colby, David W, Mirzaei, Hamid, Joachimiak, Lukasz A, Diamond, Marc I
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2018
Assuntos:
Biochemistry and Chemical Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6039173/
https://ncbi.nlm.nih.gov/pubmed/29988016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.36584
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