Codelivery of doxorubicin and JIP1 siRNA with novel EphA2-targeted PEGylated cationic nanoliposomes to overcome osteosarcoma multidrug resistance

PURPOSE: Osteosarcoma (OS) mostly affects children and young adults, and has only a 20%–30% 5-year survival rate when metastasized. We aimed to create dual-targeted (extracellular against EphA2 and intracellular against JNK-interacting protein 1 [JIP1]), doxorubicin (DOX)-loaded liposomes to treat O...

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Foilsithe in:Int J Nanomedicine
Main Authors: Haghiralsadat, Fateme, Amoabediny, Ghasem, Naderinezhad, Samira, Zandieh-Doulabi, Behrouz, Forouzanfar, Tymour, Helder, Marco N
Formáid: Artigo
Teanga:Inglês
Foilsithe: Dove Medical Press 2018
Ábhair:
Original Research
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6039070/
https://ncbi.nlm.nih.gov/pubmed/30013340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S150017
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