Preclinical mammalian safety studies of EPHARNA (DOPC nanoliposomal EphA2-targeted siRNA)

To address the need for efficient and biocompatible delivery systems for systemic siRNA delivery, we developed 1,2-Dioleoyl-sn-Glycero-3-Phosphatidylcholine (DOPC) nanoliposomal EphA2-targeted therapeutic (EPHARNA). Here, we performed safety studies of EPHARNA in murine and primate models. Single do...

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Detalhes bibliográficos
Publicado no:Mol Cancer Ther
Main Authors: Wagner, Michael J., Mitra, Rahul, McArthur, Mark J., Baze, Wallace, Barnhart, Kirstin, Wu, Sherry, Rodriguez-Aguayo, Cristian, Zhang, Xinna, Coleman, Robert L., Lopez-Berestein, Gabriel, Sood, Anil K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5457703/
https://ncbi.nlm.nih.gov/pubmed/28265009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-16-0541
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