Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer

Mutational processes underlie cancer initiation and progression. Signatures of these processes in cancer genomes may explain cancer etiology and could hold diagnostic and prognostic value. We developed a strategy that can be used to explore the origin of cancer-associated mutational signatures. We u...

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Publicat a:Science
Autors principals: Drost, Jarno, van Boxtel, Ruben, Blokzijl, Francis, Mizutani, Tomohiro, Sasaki, Nobuo, Sasselli, Valentina, de Ligt, Joep, Behjati, Sam, Grolleman, Judith E., van Wezel, Tom, Nik-Zainal, Serena, Kuiper, Roland P., Cuppen, Edwin, Clevers, Hans
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6038908/
https://ncbi.nlm.nih.gov/pubmed/28912133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aao3130
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