Nivolumab use for BRCA gene mutation carriers with recurrent epithelial ovarian cancer: A case series

Tumors deficient in DNA mismatch repair are known to display increased susceptibility to immune checkpoint inhibitors due to accumulation of DNA damage and increased neoantigen load. This suggests that deficiency in the BRCA-related DNA repair mechanism may also be a surrogate marker for immunothera...

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Bibliographic Details
Published in:Gynecol Oncol Rep
Main Authors: Matsuo, Koji, Spragg, Samantha E., Ciccone, Marcia A., Blake, Erin A., Ricker, Charité, Pham, Huyen Q., Roman, Lynda D.
Format: Artigo
Language:Inglês
Published: Elsevier 2018
Subjects:
Case Series
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6038829/
https://ncbi.nlm.nih.gov/pubmed/29998185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.gore.2018.06.011
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