Transgenic overexpression of the SUR2A-55 splice variant in mouse heart reduces infract size and promotes protective mitochondrial function

ATP-sensitive potassium channels found in both the sarcolemma (sarcK(ATP)) and mitochondria (mitoK(ATP)) of cardiomyocytes are important mediators of cardioprotection during ischemic heart disease. Sulfonylurea receptor isoforms (SUR2), encoded by Abcc9, an ATP-binding cassette family member, form r...

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Publicado en:Heliyon
Main Authors: Ramratnam, Mohun, Kenny, Barrett, Kyle, John W., Wiedmeyer, Brandi, Hacker, Timothy A., Barefield, David Y., McNally, Elizabeth M., Makielski, Jonathan C.
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6037880/
https://ncbi.nlm.nih.gov/pubmed/29998196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.heliyon.2018.e00677
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