Transgenic overexpression of the SUR2A-55 splice variant in mouse heart reduces infract size and promotes protective mitochondrial function

ATP-sensitive potassium channels found in both the sarcolemma (sarcK(ATP)) and mitochondria (mitoK(ATP)) of cardiomyocytes are important mediators of cardioprotection during ischemic heart disease. Sulfonylurea receptor isoforms (SUR2), encoded by Abcc9, an ATP-binding cassette family member, form r...

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Udgivet i:Heliyon
Main Authors: Ramratnam, Mohun, Kenny, Barrett, Kyle, John W., Wiedmeyer, Brandi, Hacker, Timothy A., Barefield, David Y., McNally, Elizabeth M., Makielski, Jonathan C.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6037880/
https://ncbi.nlm.nih.gov/pubmed/29998196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.heliyon.2018.e00677
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