The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell proliferation and targets the transcription factor Hbp1 for degradation

In yeast, the glucose-induced degradation-deficient (GID) E3 ligase selectively degrades superfluous gluconeogenic enzymes. Here, we identified all subunits of the mammalian GID/CTLH complex and provide a comprehensive map of its hierarchical organization and step-wise assembly. Biochemical reconsti...

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Udgivet i:eLife
Main Authors: Lampert, Fabienne, Stafa, Diana, Goga, Algera, Soste, Martin Varis, Gilberto, Samuel, Olieric, Natacha, Picotti, Paola, Stoffel, Markus, Peter, Matthias
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2018
Fag:
Biochemistry and Chemical Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6037477/
https://ncbi.nlm.nih.gov/pubmed/29911972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.35528
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