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Unexpectedly robust assembly of the Axin destruction complex regulates Wnt/Wg signaling in Drosophila as revealed by analysis in vivo
Secreted proteins in the Wnt family regulate gene expression in target cells by causing the accumulation of the transcriptional activator β-catenin. In the absence of Wnt, a protein complex assembled around the scaffold protein Axin targets β-catenin for destruction, thereby preventing it from trans...
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| Publicado no: | Dev Biol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6037319/ https://ncbi.nlm.nih.gov/pubmed/18561909 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2008.05.521 |
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