Resistance in In Vitro Selected Tigecycline-Resistant Methicillin-Resistant Staphylococcus aureus Sequence Type 5 Is Driven by Mutations in mepR and mepA Genes

A tigecycline-susceptible (TGC-S) Sequence Type (ST) 5 clinical methicillin-resistant Staphylococcus aureus (MRSA) strain was cultured in escalating levels of tigecycline, yielding mutants eightfold more resistant. Their genomes were sequenced to identify genetic alterations, resulting in resistance...

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Detalhes bibliográficos
Publicado no:Microb Drug Resist
Main Authors: Dabul, Andrei Nicoli Gebieluca, Avaca-Crusca, Juliana Sposto, Van Tyne, Daria, Gilmore, Michael S., Camargo, Ilana Lopes Baratella Cunha
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2018
Assuntos:
Mechanisms
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6037189/
https://ncbi.nlm.nih.gov/pubmed/29039719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/mdr.2017.0279
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