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Leptospira interrogans thermolysin refolded at high pressure and alkaline pH displays proteolytic activity against complement C3

Enzymes from the thermolysin family are crucial factors in the pathogenesis of several diseases caused by bacteria and are potential targets for therapeutic interventions. Thermolysin encoded by the gene LIC13322 of the causative agent of leptospirosis, Leptospira interrogans, was shown to cleave pr...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Biotechnol Rep (Amst)
Hauptverfasser: Chura-Chambi, Rosa Maria, Fraga, Tatiana Rodrigues, da Silva, Ludmila Bezerra, Yamamoto, Bruno Bernardi, Isaac, Lourdes, Barbosa, Angela Silva, Morganti, Ligia
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6036645/
https://ncbi.nlm.nih.gov/pubmed/29992100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.btre.2018.e00266
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