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Ubiquitin Chain Enrichment Middle-Down Mass Spectrometry (UbiChEM-MS) Reveals Cell-Cycle Dependent Formation of Lys11/Lys48 Branched Ubiquitin Chains

The dynamics of cellular signaling events are tightly regulated by a diverse set of ubiquitin chains. Recent work has suggested that branched ubiquitin chains composed of Lys11 and Lys48 isopeptide linkages play a critical role in regulating cell cycle progression. Yet, endogenous Lys11/Lys48 branch...

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Pubblicato in:J Proteome Res
Autori principali: Rana, Ambar S. J. B., Ge, Ying, Strieter, Eric R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6036340/
https://ncbi.nlm.nih.gov/pubmed/28737031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jproteome.7b00381
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