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Adapting to oxygen: 3-Hydroxyanthrinilate 3,4-dioxygenase employs loop dynamics to accommodate two substrates with disparate polarities
3-Hydroxyanthranilate 3,4-dioxygenase (HAO) is an iron-dependent protein that activates O(2) and inserts both oxygen atoms into 3-hydroxyanthranilate (3-HAA). An intriguing question is how HAO can rapidly bind O(2), even though local O(2) concentrations and diffusion rates are relatively low. Here,...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6036192/ https://ncbi.nlm.nih.gov/pubmed/29784877 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002698 |
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