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High Resolution HLA Analysis Reveals Independent Class I Haplotypes and Amino-Acid Motifs Protective for Multiple Sclerosis

We investigated association between HLA class I and class II alleles and haplotypes, and KIR loci and their HLA class I ligands, with multiple sclerosis (MS) in 412 European-American MS patients and 419 ethnically-matched controls, using next generation sequencing. The DRB1*15:01~DQB1*06:02 haplotyp...

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Vydáno v:	Genes Immun
Hlavní autoři:	Mack, Steven J., Udell, Julia, Cohen, Franziska, Osoegawa, Kazutoyo, Hawbecker, Sharon K., Noonan, David A., Ladner, Martha B., Goodridge, Damian, Trachtenberg, Elizabeth A., Oksenberg, Jorge R., Erlich, Henry A.
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	2018
Témata:	Article
On-line přístup:	https://ncbi.nlm.nih.gov/pmc/articles/PMC6035897/ https://ncbi.nlm.nih.gov/pubmed/29307888 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41435-017-0006-8
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High Resolution HLA Analysis Reveals Independent Class I Haplotypes and Amino-Acid Motifs Protective for Multiple Sclerosis

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