High Resolution HLA Analysis Reveals Independent Class I Haplotypes and Amino-Acid Motifs Protective for Multiple Sclerosis

We investigated association between HLA class I and class II alleles and haplotypes, and KIR loci and their HLA class I ligands, with multiple sclerosis (MS) in 412 European-American MS patients and 419 ethnically-matched controls, using next generation sequencing. The DRB1*15:01~DQB1*06:02 haplotyp...

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Detalhes bibliográficos
Publicado no:Genes Immun
Main Authors: Mack, Steven J., Udell, Julia, Cohen, Franziska, Osoegawa, Kazutoyo, Hawbecker, Sharon K., Noonan, David A., Ladner, Martha B., Goodridge, Damian, Trachtenberg, Elizabeth A., Oksenberg, Jorge R., Erlich, Henry A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6035897/
https://ncbi.nlm.nih.gov/pubmed/29307888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41435-017-0006-8
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