Altered thymic differentiation and modulation of arthritis by invariant NKT cells expressing mutant ZAP70

Various subsets of invariant natural killer T (iNKT) cells with different cytokine productions develop in the mouse thymus, but the factors driving their differentiation remain unclear. Here we show that hypomorphic alleles of Zap70 or chemical inhibition of Zap70 catalysis leads to an increase of I...

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Pubblicato in:Nat Commun
Autori principali: Zhao, Meng, Svensson, Mattias N. D., Venken, Koen, Chawla, Ashu, Liang, Shu, Engel, Isaac, Mydel, Piotr, Day, Jeremy, Elewaut, Dirk, Bottini, Nunzio, Kronenberg, Mitchell
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6035278/
https://ncbi.nlm.nih.gov/pubmed/29980684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05095-7
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