Altered thymic differentiation and modulation of arthritis by invariant NKT cells expressing mutant ZAP70

Various subsets of invariant natural killer T (iNKT) cells with different cytokine productions develop in the mouse thymus, but the factors driving their differentiation remain unclear. Here we show that hypomorphic alleles of Zap70 or chemical inhibition of Zap70 catalysis leads to an increase of I...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Zhao, Meng, Svensson, Mattias N. D., Venken, Koen, Chawla, Ashu, Liang, Shu, Engel, Isaac, Mydel, Piotr, Day, Jeremy, Elewaut, Dirk, Bottini, Nunzio, Kronenberg, Mitchell
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6035278/
https://ncbi.nlm.nih.gov/pubmed/29980684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05095-7
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