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A single amino acid substitution in CXCL12 confers functional selectivity at the beta-arrestin level
CXCL12/CXCR4 axis relies on both heterotrimeric G(i) protein and β-arrestin coupling to trigger downstream responses. G protein activation allows for calcium flux, chemotaxis and early extracellular-signal regulated kinases 1/2 (ERK1/2) phosphorylation, whereas β-arrestin recruitment leads to late s...
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| Publicado no: | Oncotarget |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Impact Journals LLC
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6034749/ https://ncbi.nlm.nih.gov/pubmed/29989007 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.25533 |
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