A single amino acid substitution in CXCL12 confers functional selectivity at the beta-arrestin level

CXCL12/CXCR4 axis relies on both heterotrimeric G(i) protein and β-arrestin coupling to trigger downstream responses. G protein activation allows for calcium flux, chemotaxis and early extracellular-signal regulated kinases 1/2 (ERK1/2) phosphorylation, whereas β-arrestin recruitment leads to late s...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Oncotarget
Päätekijät: Rigo, Antonella, Ferrarini, Isacco, Innamorati, Giulio, Vinante, Fabrizio
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Impact Journals LLC 2018
Aiheet:
Research Paper
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6034749/
https://ncbi.nlm.nih.gov/pubmed/29989007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.25533
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia