A single amino acid substitution in CXCL12 confers functional selectivity at the beta-arrestin level

CXCL12/CXCR4 axis relies on both heterotrimeric G(i) protein and β-arrestin coupling to trigger downstream responses. G protein activation allows for calcium flux, chemotaxis and early extracellular-signal regulated kinases 1/2 (ERK1/2) phosphorylation, whereas β-arrestin recruitment leads to late s...

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Udgivet i:Oncotarget
Main Authors: Rigo, Antonella, Ferrarini, Isacco, Innamorati, Giulio, Vinante, Fabrizio
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2018
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6034749/
https://ncbi.nlm.nih.gov/pubmed/29989007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.25533
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