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A single amino acid substitution in CXCL12 confers functional selectivity at the beta-arrestin level
CXCL12/CXCR4 axis relies on both heterotrimeric G(i) protein and β-arrestin coupling to trigger downstream responses. G protein activation allows for calcium flux, chemotaxis and early extracellular-signal regulated kinases 1/2 (ERK1/2) phosphorylation, whereas β-arrestin recruitment leads to late s...
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| 出版年: | Oncotarget |
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| 主要な著者: | , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Impact Journals LLC
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6034749/ https://ncbi.nlm.nih.gov/pubmed/29989007 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.25533 |
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