Interaction of Huntingtin Exon-1 Peptides with Lipid-Based Micellar Nanoparticles Probed by Solution NMR and Q-Band Pulsed EPR

Lipid-based micellar nanoparticles promote aggregation of huntingtin exon-1 peptides. Here we characterize the interaction of two such peptides, htt(NT)Q(7) and htt(NT)Q(10) comprising the N-terminal amphiphilic domain of huntingtin followed by 7 and 10 glutamine repeats, respectively, with 8 nm lip...

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Publicado en:J Am Chem Soc
Main Authors: Ceccon, Alberto, Schmidt, Thomas, Tugarinov, Vitali, Kotler, Samuel A., Schwieters, Charles D., Clore, G. Marius
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6034506/
https://ncbi.nlm.nih.gov/pubmed/29727175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b02619
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