Mediation analysis to understand genetic relationships between habitual coffee intake and gout

BACKGROUND: Increased coffee intake is associated with reduced serum urate concentrations and lower risk of gout. Specific alleles of the GCKR, ABCG2, MLXIPL, and CYP1A2 genes have been associated with both reduced coffee intake and increased serum urate in separate genome-wide association studies (...

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Bibliographic Details
Published in:Arthritis Res Ther
Main Authors: Hutton, Joseph, Fatima, Tahzeeb, Major, Tanya J., Topless, Ruth, Stamp, Lisa K., Merriman, Tony R., Dalbeth, Nicola
Format: Artigo
Language:Inglês
Published: BioMed Central 2018
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6034252/
https://ncbi.nlm.nih.gov/pubmed/29976226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-018-1629-5
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