Mediation analysis to understand genetic relationships between habitual coffee intake and gout

BACKGROUND: Increased coffee intake is associated with reduced serum urate concentrations and lower risk of gout. Specific alleles of the GCKR, ABCG2, MLXIPL, and CYP1A2 genes have been associated with both reduced coffee intake and increased serum urate in separate genome-wide association studies (...

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Vydáno v:Arthritis Res Ther
Hlavní autoři: Hutton, Joseph, Fatima, Tahzeeb, Major, Tanya J., Topless, Ruth, Stamp, Lisa K., Merriman, Tony R., Dalbeth, Nicola
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2018
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6034252/
https://ncbi.nlm.nih.gov/pubmed/29976226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-018-1629-5
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