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N-Gemini peptides: cytosolic protease resistance via N-terminal dimerization of unstructured peptides
Herein we describe a synthetically simple strategy for increasing the lifetime of unstructured peptides in cytosolic environment via dimerization at the N-terminus to block threading into the catalytic cleft of cytosolic proteases. We establish this approach with kinase substrates, allowing for phos...
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| Publicado no: | Chem Commun (Camb) |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6034174/ https://ncbi.nlm.nih.gov/pubmed/29230440 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7cc06819k |
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