Secretagogin protects Pdx1 from proteasomal degradation to control a transcriptional program required for β cell specification

OBJECTIVE: Specification of endocrine cell lineages in the developing pancreas relies on extrinsic signals from non-pancreatic tissues, which initiate a cell-autonomous sequence of transcription factor activation and repression switches. The steps in this pathway share reliance on activity-dependent...

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Bibliographic Details
Published in:Mol Metab
Main Authors: Malenczyk, Katarzyna, Szodorai, Edit, Schnell, Robert, Lubec, Gert, Szabó, Gábor, Hökfelt, Tomas, Harkany, Tibor
Format: Artigo
Language:Inglês
Published: Elsevier 2018
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6034064/
https://ncbi.nlm.nih.gov/pubmed/29910119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2018.05.019
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