A TRPV1‐to‐secretagogin regulatory axis controls pancreatic β‐cell survival by modulating protein turnover

Ca(2+)‐sensor proteins are generally implicated in insulin release through SNARE interactions. Here, secretagogin, whose expression in human pancreatic islets correlates with their insulin content and the incidence of type 2 diabetes, is shown to orchestrate an unexpectedly distinct mechanism. Singl...

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Publicado no:EMBO J
Main Authors: Malenczyk, Katarzyna, Girach, Fatima, Szodorai, Edit, Storm, Petter, Segerstolpe, Åsa, Tortoriello, Giuseppe, Schnell, Robert, Mulder, Jan, Romanov, Roman A, Borók, Erzsébet, Piscitelli, Fabiana, Di Marzo, Vincenzo, Szabó, Gábor, Sandberg, Rickard, Kubicek, Stefan, Lubec, Gert, Hökfelt, Tomas, Wagner, Ludwig, Groop, Leif, Harkany, Tibor
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5510001/
https://ncbi.nlm.nih.gov/pubmed/28637794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201695347
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