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H3.3K27M mutant proteins reprogram epigenome by sequestering the PRC2 complex to poised enhancers
Expression of histone H3.3K27M mutant proteins in human diffuse intrinsic pontine glioma (DIPG) results in a global reduction of tri-methylation of H3K27 (H3K27me3), and paradoxically, H3K27me3 peaks remain at hundreds of genomic loci, a dichotomous change that lacks mechanistic insights. Here, we s...
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| Publicado no: | eLife |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6033537/ https://ncbi.nlm.nih.gov/pubmed/29932419 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.36696 |
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