Targeting of BMI-1 expression by the novel small molecule PTC596 in mantle cell lymphoma

Despite the development of the novel Bruton tyrosine kinase inhibitor ibrutinib, mantle cell lymphoma (MCL) remains an incurable B-cell non-Hodgkin lymphoma. BMI-1 is required for the self-renewal and maintenance of MCL-initiating stem cells. Upregulation of BMI-1 has been reported in MCL patients,...

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Vydáno v:Oncotarget
Hlavní autoři: Maeda, Aya, Nishida, Yuki, Weetall, Marla, Cao, Liangxian, Branstrom, Arthur, Ishizawa, Jo, Nii, Takenobu, Schober, Wendy D., Abe, Yoshiaki, Matsue, Kosei, Yoshimura, Mariko, Kimura, Shinya, Kojima, Kensuke
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2018
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6033370/
https://ncbi.nlm.nih.gov/pubmed/29983879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.25558
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