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Highly Selective Directed Iridium‐Catalyzed Hydrogen Isotope Exchange Reactions of Aliphatic Amides

For the first time, we describe highly selective homogeneous iridium‐catalyzed hydrogen isotope exchange (HIE) of unactivated C(sp(3)) centers in aliphatic amides. When using the commercially available Kerr catalyst, the HIE with a series of common antibody–drug conjugate (ADC) linker side chains pr...

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Bibliografische gegevens
Gepubliceerd in:Angew Chem Int Ed Engl
Hoofdauteurs: Valero, Mégane, Weck, Remo, Güssregen, Stefan, Atzrodt, Jens, Derdau, Volker
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2018
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6033151/
https://ncbi.nlm.nih.gov/pubmed/29693316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201804010
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