Ibrutinib for chronic graft-versus-host disease after failure of prior therapy

Chronic graft-versus-host disease (cGVHD) is a serious complication of allogeneic stem cell transplantation with few effective options available after failure of corticosteroids. B and T cells play a role in the pathophysiology of cGVHD. Ibrutinib inhibits Bruton tyrosine kinase in B cells and inter...

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Bibliographic Details
Published in:Blood
Main Authors: Miklos, David, Cutler, Corey S., Arora, Mukta, Waller, Edmund K., Jagasia, Madan, Pusic, Iskra, Flowers, Mary E., Logan, Aaron C., Nakamura, Ryotaro, Blazar, Bruce R., Li, Yunfeng, Chang, Stephen, Lal, Indu, Dubovsky, Jason, James, Danelle F., Styles, Lori, Jaglowski, Samantha
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2017
Subjects:
Plenary Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6033048/
https://ncbi.nlm.nih.gov/pubmed/28924018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-07-793786
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