7‐Step Flow Synthesis of the HIV Integrase Inhibitor Dolutegravir

Dolutegravir (DTG), an important active pharmaceutical ingredient (API) used in combination therapy for the treatment of HIV, has been synthesized in continuous flow. By adapting the reported GlaxoSmithKline process chemistry batch route for Cabotegravir, DTG was produced in 4.5 h in sequential flow...

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Dades bibliogràfiques
Publicat a:Angew Chem Int Ed Engl
Autors principals: Ziegler, Robert E., Desai, Bimbisar K., Jee, Jo‐Ann, Gupton, B. Frank, Roper, Thomas D., Jamison, Timothy F.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2018
Matèries:
Communications
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6033037/
https://ncbi.nlm.nih.gov/pubmed/29756689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201802256
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