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Asymmetric Reductive Carbocyclization Using Engineered Ene Reductases
Ene reductases from the Old Yellow Enzyme (OYE) family reduce the C=C double bond in α,β‐unsaturated compounds bearing an electron‐withdrawing group, for example, a carbonyl group. This asymmetric reduction has been exploited for biocatalysis. Going beyond its canonical function, we show that member...
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| Pubblicato in: | Angew Chem Int Ed Engl |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
John Wiley and Sons Inc.
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6033016/ https://ncbi.nlm.nih.gov/pubmed/29689601 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201802962 |
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