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Identification of promiscuous ene-reductase activity by mining structural databases using active site constellations
The exploitation of catalytic promiscuity and the application of de novo design have recently opened the access to novel, non-natural enzymatic activities. Here we describe a structural bioinformatic method for predicting catalytic activities of enzymes based on three-dimensional constellations of f...
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| Autors principals: | , , , , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Pub. Group
2014
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4083419/ https://ncbi.nlm.nih.gov/pubmed/24954722 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms5150 |
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