Identification of promiscuous ene-reductase activity by mining structural databases using active site constellations

The exploitation of catalytic promiscuity and the application of de novo design have recently opened the access to novel, non-natural enzymatic activities. Here we describe a structural bioinformatic method for predicting catalytic activities of enzymes based on three-dimensional constellations of f...

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Main Authors: Steinkellner, Georg, Gruber, Christian C., Pavkov-Keller, Tea, Binter, Alexandra, Steiner, Kerstin, Winkler, Christoph, Łyskowski, Andrzej, Schwamberger, Orsolya, Oberer, Monika, Schwab, Helmut, Faber, Kurt, Macheroux, Peter, Gruber, Karl
Format: Artigo
Sprog:Inglês
Udgivet: Nature Pub. Group 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4083419/
https://ncbi.nlm.nih.gov/pubmed/24954722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms5150
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