Role of TLR4 signaling in the nephrotoxicity of heme and heme proteins

Destabilized heme proteins release heme, and free heme is toxic. Heme is now recognized as an agonist for the Toll-like receptor-4 (TLR4) receptor. This study examined whether the TLR4 receptor mediates the nephrotoxicity of heme, specifically, the effects of heme on renal blood flow and inflammator...

Full description

Saved in:
Bibliographic Details
Published in:Am J Physiol Renal Physiol
Main Authors: Nath, Karl A., Belcher, John D., Nath, Meryl C., Grande, Joseph P., Croatt, Anthony J., Ackerman, Allan W., Katusic, Zvonimir S., Vercellotti, Gregory M.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2018
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6031913/
https://ncbi.nlm.nih.gov/pubmed/28978536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00432.2017
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items