Role of TLR4 signaling in the nephrotoxicity of heme and heme proteins

Destabilized heme proteins release heme, and free heme is toxic. Heme is now recognized as an agonist for the Toll-like receptor-4 (TLR4) receptor. This study examined whether the TLR4 receptor mediates the nephrotoxicity of heme, specifically, the effects of heme on renal blood flow and inflammator...

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Détails bibliographiques
Publié dans:Am J Physiol Renal Physiol
Auteurs principaux: Nath, Karl A., Belcher, John D., Nath, Meryl C., Grande, Joseph P., Croatt, Anthony J., Ackerman, Allan W., Katusic, Zvonimir S., Vercellotti, Gregory M.
Format: Artigo
Langue:Inglês
Publié: American Physiological Society 2018
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Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6031913/
https://ncbi.nlm.nih.gov/pubmed/28978536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00432.2017
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