Inhibition of TBC1D5 activates Rab7a and can enhance the function of the retromer cargo-selective complex

The retromer complex is a vital component of the endosomal protein sorting machinery necessary for sorting into both the endosome-to-Golgi retrieval pathway and also the endosome-to-cell-surface recycling pathway. Retromer mediates cargo selection through a trimeric complex comprising VPS35, VPS29 a...

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Bibliographic Details
Published in:J Cell Sci
Main Authors: Seaman, Matthew N. J., Mukadam, Aamir S., Breusegem, Sophia Y.
Format: Artigo
Language:Inglês
Published: The Company of Biologists Ltd 2018
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6031384/
https://ncbi.nlm.nih.gov/pubmed/29777037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.217398
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