Inhibition of TBC1D5 activates Rab7a and can enhance the function of the retromer cargo-selective complex

Eitemau Tebyg

• Membrane recruitment of the cargo-selective retromer subcomplex is catalysed by the small GTPase Rab7 and inhibited by the Rab-GAP TBC1D5
  gan: Seaman, Matthew N. J., et al.
  Cyhoeddwyd: (2009)
• The cargo-selective retromer complex is a recruiting hub for protein complexes that regulate endosomal tubule dynamics
  gan: Harbour, Michael E., et al.
  Cyhoeddwyd: (2010)
• Control of RAB7 activity and localization through the retromer‐TBC1D5 complex enables RAB7‐dependent mitophagy
  gan: Jimenez‐Orgaz, Ana, et al.
  Cyhoeddwyd: (2017)
• Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer
  gan: Seaman, Matthew N.J.
  Cyhoeddwyd: (2004)
• Analysis of novel endosome-to-Golgi retrieval genes reveals a role for PLD3 in regulating endosomal protein sorting and amyloid precursor protein processing
  gan: Mukadam, Aamir S., et al.
  Cyhoeddwyd: (2018)