A BK channel–mediated feedback pathway links single-synapse activity with action potential sharpening in repetitive firing

Action potential shape is a major determinant of synaptic transmission, and mechanisms of spike tuning are therefore of key functional significance. We demonstrate that synaptic activity itself modulates future spikes in the same neuron via a rapid feedback pathway. Using Ca(2+) imaging and targeted...

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Bibliografske podrobnosti
izdano v:Sci Adv
Main Authors: Roshchin, Matvey V., Matlashov, Mikhail E., Ierusalimsky, Victor N., Balaban, Pavel M., Belousov, Vsevolod V., Kemenes, György, Staras, Kevin, Nikitin, Evgeny S.
Format: Artigo
Jezik:Inglês
Izdano: American Association for the Advancement of Science 2018
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6031373/
https://ncbi.nlm.nih.gov/pubmed/29978045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aat1357
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