Impaired β-cell glucokinase as an underlying mechanism in diet-induced diabetes

High-fat diet (HFD)-fed mouse models have been widely used to study early type 2 diabetes. Decreased β-cell glucokinase (GCK) expression has been observed in HFD-induced diabetes. However, owing to its crucial roles in glucose metabolism in the liver and in islet β-cells, the contribution of decreas...

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Foilsithe in:Dis Model Mech
Main Authors: Lu, Brian, Kurmi, Kiran, Munoz-Gomez, Miguel, Jacobus Ambuludi, Egon J., Tonne, Jason M., Rakshit, Kuntol, Hitosugi, Taro, Kudva, Yogish C., Matveyenko, Aleksey V., Ikeda, Yasuhiro
Formáid: Artigo
Teanga:Inglês
Foilsithe: The Company of Biologists Ltd 2018
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6031355/
https://ncbi.nlm.nih.gov/pubmed/29915142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.033316
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