Impaired β-cell glucokinase as an underlying mechanism in diet-induced diabetes

High-fat diet (HFD)-fed mouse models have been widely used to study early type 2 diabetes. Decreased β-cell glucokinase (GCK) expression has been observed in HFD-induced diabetes. However, owing to its crucial roles in glucose metabolism in the liver and in islet β-cells, the contribution of decreas...

Full description

Saved in:
Bibliographic Details
Published in:Dis Model Mech
Main Authors: Lu, Brian, Kurmi, Kiran, Munoz-Gomez, Miguel, Jacobus Ambuludi, Egon J., Tonne, Jason M., Rakshit, Kuntol, Hitosugi, Taro, Kudva, Yogish C., Matveyenko, Aleksey V., Ikeda, Yasuhiro
Format: Artigo
Language:Inglês
Published: The Company of Biologists Ltd 2018
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6031355/
https://ncbi.nlm.nih.gov/pubmed/29915142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.033316
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items