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Impaired β-cell glucokinase as an underlying mechanism in diet-induced diabetes
High-fat diet (HFD)-fed mouse models have been widely used to study early type 2 diabetes. Decreased β-cell glucokinase (GCK) expression has been observed in HFD-induced diabetes. However, owing to its crucial roles in glucose metabolism in the liver and in islet β-cells, the contribution of decreas...
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| Izdano u: | Dis Model Mech |
|---|---|
| Glavni autori: | , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
The Company of Biologists Ltd
2018
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6031355/ https://ncbi.nlm.nih.gov/pubmed/29915142 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.033316 |
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