Dipeptide repeat proteins activate a heat shock response found in C9ORF72-ALS/FTLD patients

A hexanucleotide (GGGGCC) repeat expansion in C9ORF72 is the most common genetic contributor to amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Reduced expression of the C9ORF72 gene product has been proposed as a potential contributor to disease pathogenesis. Addit...

詳細記述

保存先:
書誌詳細
出版年:Acta Neuropathol Commun
主要な著者: Mordes, Daniel A., Prudencio, Mercedes, Goodman, Lindsey D., Klim, Joseph R., Moccia, Rob, Limone, Francesco, Pietilainen, Olli, Chowdhary, Kaitavjeet, Dickson, Dennis W., Rademakers, Rosa, Bonini, Nancy M., Petrucelli, Leonard, Eggan, Kevin
フォーマット: Artigo
言語:Inglês
出版事項: BioMed Central 2018
主題:
Research
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6031111/
https://ncbi.nlm.nih.gov/pubmed/29973287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-018-0555-8
タグ: タグ追加
タグなし, このレコードへの初めてのタグを付けませんか!

類似資料